Association between the synonymous variant organic cation transporter 3 (OCT3)-1233G>A and the glycemic response following metformin therapy in patients with type 2 diabetes
نویسندگان
چکیده مقاله:
Objective(s): Organic cation transporter 3 (OCT3) as a high-capacity transporter contribute to the metabolism of metformin. The present study was conducted to determine the genotype frequencies of the variant OCT3-1233G>A (rs2292334) in patients with newly diagnosed type 2 diabetes (T2D) and its relationship with response to metformin. Materials and Methods: This study included 150 patients with T2D who were classified into two groups following three months of metformin therapy: responders (by more than 1% reduction in HbA1c from baseline) and nonresponders (less than 1% reduction in HbA1c from baseline). PCR-based restriction fragment length polymorphism (RFLP) served to genotype OCT3-564G>A variant. Results: The parameters such as HbA1c (PA variant in our study and different ethnic populations confirm that the variant is a highly polymorphic variant.
منابع مشابه
association between the synonymous variant organic cation transporter 3 (oct3)-1233g>a and the glycemic response following metformin therapy in patients with type 2 diabetes
objective(s): organic cation transporter 3 (oct3) as a high-capacity transporter contribute to the metabolism of metformin. the present study was conducted to determine the genotype frequencies of the variant oct3-1233g>a (rs2292334) in patients with newly diagnosed type 2 diabetes (t2d) and its relationship with response to metformin. materials and methods: this study included 150 patients wit...
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عنوان ژورنال
دوره 20 شماره 3
صفحات 250- 255
تاریخ انتشار 2017-03-01
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